The goal of chromatographic method development is to find methods that reproducibly separate the compounds of interest. Depending
on the samples complexity, the strategies involved can be very complex. LC-UV is usually applied for UV-peak tracking and simple, known samples. Complex, unknown samples
can be resolved with MS/UV peak tracking.
ACD/Labs philosophy for computer-assisted modelling and simulation in chromatography can significantly improve the efficiency of chromatographic method development [1].
Chromatographic and spectral data can be imported from most instruments, while the method development and structure confirmation are done with sophisticated algorithms.
Selectivity can be achieved by modifying the stationary and mobile phases, using gradients or controlling the temperature. All these parameters can contribute to a
multi-dimensional modelling and optimisation strategy.
ACD/AutoChrom facilitates the automation of data acquisition and processing, and allows the creation of efficient strategies [2].
Quality by Design methodologies can help the method development process [3].
ACD/Spectrus is a new, revolutionary concept, allowing the integration of analytical data from a variety of analytical methods, and capturing the relevant information
in intelligent databases for future reference [4].
References
[1]. Bogomolov, A., M. McBrien,
Anal. Chim. Acta, 490: 41–58,
2003.
[2]. Stafford, J.D., Maloney, T.D, Myers, D.P., Cintron, J.M., Castle, B.C,
J. Pharm. Biomed. Anal., 56: 280-292,
2011.
[3]. McBrien, M.,
Chromatography Today, May/June: 30-34,
2010.
[4].
ACD/Spectrus Processor
