ACD/Method Development Suite for LC/UV

What's New

Version 10.0 to 11.0

Improvements to Automated Peak Matching

• Overlay UV spectra for comparison of components across injections
• New option to assign newly extracted components as Rejected or Irrelevant
• UV-Mutual Automated Peak Matching enhancements
  • Specify the minimum number of injections in which a component must be detected in order to be Relevant
  • Ignore components that are not detected at all pH values
  • Improved quality of LC/UV peak picking

Improvements to Component Reconciliation

• Control the accuracy of component reconciliation

Enhanced Strategy Creation

• Update the instrument configuration over the course of a project to expand the experimental design space
• Column screening strategy creation now considers the % minimum organic value
• Merge or split waves

Advancements to the Table of Components

• Switch between the Table of Components (all components for the project are listed) and a new Table of Peaks (only components detected in the current experiment)
• Transfer peak labels between detectors (e.g., LC/DAD and single-wavelength chromatogram) from the same injection
• New command to erase all unassigned peaks
• New command to clear all peak labels

Changes to the Experiments Subwindow

• Two new data columns—number of rejected peaks, and number of unnamed peaks added to Experiments table
• Error check process for file reimport

Improved Ease-of-Use

• Create retention models for method optimization within the AutoChrom Console Task window
• Execute default commands on double-click for most subwindows

Additional Features

• Create ACD/ChromGenius databases from Method Development Suite projects

Download a PDF copy of the expanded details on What's New with ACD/Method Development Suite for LC/UV, or contact your Account Manager or Distributor.

Version 9.0 to 10.0

ACD/Method Development Suite has been renamed ACD/Method Development Suite for LC/UV for version 10.0. You may also be interested in new ACD/Method Development Suite for LC/MS, which provides additional support for LC/MS data.

Automated Peak Matching between LC/UV Datasets

Project Management

• Manage and summarize all files associated with method development project:
  • View a collapsible Table of Peaks which summarizes your injections
  • Manage and summarize composite samples, and visualize composite chromatograms
  • Store your experimental data and LC Simulator predictions in one place, to quickly understand the rationale behind your experiments
  • View chromatograms and spectra alongside your peak tables

Method Development Assistant

• Guided method development
  • Configure method development strategies
  • Software suggests the next experiment based on ACD/LC Simulator optimization

New Processing Features

• Automatic attachment of chemical structures from an SDfile to labeled chromatographic peaks
• Automatic attachment of chemical structures to chromatograms by sample name

LC/UV Processing

• Peak picking for LC/UV (DAD, PDA) datafiles, not simply the Total Absorbance Chromatogram as in previous versions
  • Retention time, peak height, and wavelength of the peak maximum in the UV-spectrum are added to the Table of Peaks
  • UV-spectrum is retained
• Automatic baseline correction for LC/UV datafiles removes the spectrum of the solvent background
• Peak picking now available for Single UV-Trace(s0, not simply the Total Absorbance Chromatogram
• Transfer peak information from one LC/UV dataset to another with Manual Peak Matching tool

Enhancements to file import:

• Method parameters may now be imported directly from 32-bit Agilent ChemStation files.
• Import is now available for Waters Empower 2 files.
  • Includes direct import of LC/UV (PDA) files.
• Direct import of HPLC parameters and gradient program(s) from Waters MassLynx LC/UV (PDA) files.
• Direct import of HPLC parameters and gradient program(s) from Agilent ChemStation LC/UV (DAD) files

ACD/Chromatography Applications Database increased in size, and now contains 7349 applications.