ACD/LC & GC Simulator—Model and Optimize LC and GC Separation Methods

Apply QbD Principles to Optimize Method Development Based on Your Experimental Data

ACD/LC & GC Simulator - Model and Optimize LC and GC Separation Methods

ACD/LC and GC Simulator applies Quality by Design (QbD) principles such as expanding design space, and multivariate optimization to help you optimize gradient and temperature to achieve optimal resolution of your separation during method development. ACD/LC and GC Simulator model chromatograms and predict optimal separation conditions and retention times for your compounds using experimental data and physicochemical property predictions.


  • Optimize your gradient, solvent ratio and concentration, temperature, pH, and more
  • Predict retention times for new compounds under existing methods
  • Automatically match peaks between LC/UV (DAD, PDA) datasets based on spectral similarity
  • Visualize the effect of changing your method conditions with predicted chromatograms
  • A variety of models available for optimizing separations (proteins, HILIC, etc.)
  • Process raw chromatographic data from many different vendor instruments


  • Quickly optimize methods in less time with fewer injections
  • Eliminate manual peak matching between runs

Additional Resources

LC FeaturesLC Features

GC FeaturesGC Features

Processing FeaturesProcessing Features

Supported File FormatsSupported File Formats