ACD/Oral Bioavailability

Predict endpoints affecting bioavailability including solubility, P-gp efflux, acid stability, and first pass metabolism from structure

The oral bioavailability module uses a combination of probabilistic and mechanistic modeling techniques to predict oral bioavailability from structure, and relies on a number of other ACD/Labs prediction algorithms and experimental data sets. Results are provided as a quantitative prediction of bioavailability after oral administration (%F) of a dose defined by the user.

About the Model

Data Sources—various peer-reviewed scientific journals, and reference books:

  • Therapeutic Drugs, Dollery, C., Ed. 2nd Edition, Churchill Livingstone, New York, NY, 1999
  • Clarke's Isolation and Identification of Drugs, Moffat, A. C., Jackson, J.V., Moss, M.S., Widdop, B., Eds. 2nd Edition, The Pharmaceutical Press, London, 1986

Other Products

ACD/Oral Bioavailability Model predictions are available as a browser-based thin client application on ACD/Percepta Portal; a thick client product (ACD/Percepta for the Desktop); and a batch calculator (ACD/Percepta Batch).