January 19, 2006, ACD/Labs NJ NMR Meeting, New Brunswick, NJ

Indirect Covariance NMR Spectroscopy

G.E. Martin, M. Zell, & K.A. Mills, Pfizer and
K.A. Blinov, N.I. Larin, M.P. Kvasha, & A.J. Williams, ACD/Labs

Abstract

This presentation describes recent advancements in the area of indirect covariance NMR spectroscopy reported in a series of publications. The presentation will begin with the identification of two types of artifact responses in the indirect covariance spectra and then introduces the concept of unsymmetrical indirect covariance processing as a means of eliminating these artifacts. The unsymmetrical indirect covariance processing software is next used to co-process discretely-acquired HSQC and HMBC experiments to give the long-range carbon-carbon connectivity information equivalent to that of an n,n-ADEQUATE experiment without ever having to acquire these low sensitivity data. Finally, the talk will illustrate the co-processing of HSQC and COSY experimental data to give the mathematical equivalent of HSQC-COSY spectra with better signal-to-noise in a substantially shorter period of time than required to actually perform an HSQC-COSY or -TOCSY experiment.

Download the presentation in MS PowerPoint (4.01 Mb ZIP file) or Adobe Acrobat format (741 Kb PDF file).