The Column; 2006; 12

Systematic Development of Stability-Indicating Methods

Michael McBrien, Margaret Antler

Abstract

This article discusses some of the benefits and challenges associated with maintaining individual degradation samples for LC-MS-UV method development. The latest advancements for automated LC-MS and LC-UV peak tracking and detector reconciliation, are described. These advancements allow a virtual composite sample to be created post data acquisition and transferred to LC optomization software for systematic, efficient method development.

Download the article from the The Column Web Site.