Better, Faster Method Development at Janssen

Over a 14-year period, the small molecules method development team in the analytical group at Janssen Pharmaceuticals led by Rudy Sneyers pursued a methodical process to improve both time and quality. The resulting case study outlines the steps taken and progress gained throughout the process.

As Rudy noted, “I told my colleagues it has to be possible to reach both of these goals, and, indeed, we reached them.” A comparison of the key performance indicators for AutoChrom UPLC–Twins [LC-UV-MS] with those of the trial-and-error starting point substantiate this claim: Janssen achieved an 80% reduction in method development time, and a 25-fold improvement in quality. Furthermore, the investment for AutoChrom UPLC–Twins [LC-UV-MS] is only slightly more than the savings in personnel cost, due in large part to the automation of manual operations, especially the raw-data evaluations of multiple chromatographs.

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