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ACD/Labs Blog

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A new strategy for the identification of known compounds in Streptomyces extracts that can be applied in the discovery of natural products is presented. The strategy incorporates screening a database of 5555 natural products including 5098 structures from Streptomyces sp. A spectral database named MbcDB was generated using the ACD/Spectrus DB Platform. The structures were...

nvision-joelm
A new strategy for the identification of known compounds in Streptomyces extracts that can be applied in the discovery of natural products is presented. The strategy incorporates screening a database of 5555 natural products including 5098 structures from Streptomyces sp. A spectral database named MbcDB was generated using the ACD/Spectrus DB Platform. The structures were...

nvision-joelm
Dereplication refers to the process of screening active compounds early in the development process to recognize and eliminate those compounds that have been studied in the past, thereby proactively decreasing the number of structures that will need to be fully elucidated and minimizing the amount of time spent on testing.

nvision-joelm
A major problem in the discovery of new biologically active compounds from natural products is the re-isolation of known compounds. To address this problem, dereplication strategies are needed that enable crude extracts to be screened for the presence of known compounds before isolation efforts are initiated. The specific attributes of this dereplication methodology include a...