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ACD/Labs Blog

Imad Haidar Ahmad and colleagues at Merck present multifactorial peak crossover (MPC)—a new technique to quickly isolate peaks of interest. Using computer-assisted chromatographic modelling, the separation landscape is mapped and conditions that change peak-elution orders are found. Peaks of interest can be quickly shifted to convenient areas of the chromatogram, dramatically reducing the time spent...

In LC Method Development I to III, we covered the key points of method development: figuring out the project purpose, choosing parameters for screening, and optimizing. How do you assemble all these components into one workflow and manage them efficiently? This webinar puts it all together by showing you how to manage your projects from...

Optimized LC methods give the results you need to satisfy customers, synthetic chemists, QC teams, and other end users. Compared to trial and error, a proper optimization process saves time and resources. And with optimization software, you can get even more efficient. In this webinar, we’ll cover the principles you need to know for method...

Method development is a journey into the unknown. The destination may be clear enough, if you’ve defined your project goals. But unforeseen challenges lurk to trip up the unwary chromatographer. Before you know it, your two-week project has become a six-week odyssey, with events like: “Where did my compound go?” “Why are my peaks lopsided?”...

Chromatographers often speak of developing methods and separating compounds—two related but not identical ideas. Besides separating analytes, a high-quality method must meet many other criteria, including robustness, linearity, and limits of detection. To specify these factors, scientists must start with defined goals. What do you need the method to tell you? And how do you...