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Logic Puzzle #37: HSQC or TOCSY, the correlations both look the same!

November 9, 2012

Depending on the mixing time, HSQC-TOCSY experiments generally offer information on both short-range and long-range coupled nuclei. The issue arises in sorting out the HSQC correlations from the TOCSY ones.

For an unknown compound, a 1H -13C HSQC-TOCSY spectrum was collected. The expanded region of the spectrum below shows several correlations. How many HSQC-related correlations are there? How many TOCSY-related correlations are evident?

Thank you Gary M. for supplying the data.

One Reply to “Logic Puzzle #37: HSQC or TOCSY, the correlations both look the same!”

  1. One could always run a IDR-HSQC-TOCSY (Inverse Direct Response), where TOCSY and HSQC peaks have opposite phase …

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