June 29, 2010
The goal of this puzzle is to resolve the ambiguity exhibited within a 2D NMR spectrum and thus provide the correct signal correlation.
The following 1H-13C HSQC-DEPT NMR spectrum shows two one-bond correlations linked to the 1H signals 2.75 and 3.50 ppm and two closely spaced 13C signals at 61.5 and 62.2 ppm. Does the 1H signal at 2.75 ppm correlate to the 13C signal at 61.5 ppm or the one at 62.2 ppm?
Note: the blue line was added to help align the correlation to the F1 domain.