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A 1H-1H COSY dataset provides information on coupled spin systems. A coupled spin system does not necessarily imply that the protons are bonded to only carbon atoms . An example of an exchangeable proton (OH) coupled to a proton from a CH group is shown below. Three spectral datasets, 1H NMR, HMQC and a COSY-45...

A very useful bit of information on the proton count comes from integrating a 1H NMR spectrum. However, overlapping resonances can make integration less than straightforward and in some cases ambiguous. Integration involves the following decisions to be made by the elucidator: which resonances to integrate, where the integral begins and ends, and what the...

A biased elucidation is an elucidation where the chemist makes certain assumptions about the data at hand based on a previous experience(s) and not deviating from it. Depending on the elucidation, it can be a good thing or a very bad thing. As a good thing, it can speed up the time spent on an...

Depending on the experimental conditions, signals from exchangeable protons such as NH and OH can be present on a 1H NMR spectrum. A key to interpreting a 1H NMR is distinguishing between CHn protons (where n = 1, 2 or 3) and exchangeable protons. Acquiring an 1H-13C 2D NMR experiment can assist in this process,...