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Faster, More Sensitive 2D NMR and Indirect Covariance

Interesting article from C&E News, about faster and more sensitive 2D NMR.

"The merging of techniques (ultrafast multidimensional NMR and ex situ hyperpolarized dynamic nuclear polarization), makes it possible "to collect 2-D NMR data within a fraction of a
second, instead of the minutes to hours normally required for
conventional 2-D NMR acquisitions," Frydman says. And it makes it
possible to analyze samples with submicromolar concentrations, whereas
millimolar concentration limits are more typical of conventional NMR,
he says."

Interesting stuff indeed, unfortunately I don’t know that you’ll go ahead and make use of this application today. Further, what does this story have to do with software (the purpose of my blog?).

Well, nothing for now.

But if you have ever found yourself in the dilemma where you would like to run hyphenated 2D NMR data but can’t afford the spectrometer time it will eat up, or if your product has long since decomposed,  I might have some interesting stuff for you.

At ENC 2007, Gary Martin from Schering-Plough spoke in the liquids session, as well as at our annual seminar. He spoke about Unsymmetrical Indirect Covariance. His talk was extremely well received at the conference (The most common question in our suite all week was, "Do you have more information on that stuff Gary Martin was talking about?"). His abstract and presentation can be downloaded here:

http://www.acdlabs.com/publish/publ07/enc2007_indirect_covariance_nmr.html

Following Gary’s talk, my colleague, Arvin Moser gave a talk on how to perform indirect covariance in ACD/2D NMR Processor. His abstract and presentation is here:

http://www.acdlabs.com/publish/publ07/enc2007_covariance.html

For step-by-step instructions, Arvin has also written two technical notes:

One on how to perform indirect covariance in ACD/2D NMR Processor:

http://www.acdlabs.com/download/technotes/90/nmr/indirectcovariance_amfinal.pdf

and one on how to perform unsymmetrical indirect covariance in ACD/2D NMR Processor:

http://www.acdlabs.com/download/technotes/90/nmr/unsumm_covariance.pdf

Oh yeah…and a laundry list of publications we have collaborated with others on:

Utilizing Unsymmetrical Indirect Covariance Processing to Define 13C-15N Connectivity Networks
Kirill A. Blinov,  Antony J. Williams, P.A. Irish (Schering-Plough), Bruce D. Hilton (Schering-Plough), and Gary E. Martin (Schering-Plough)
Magn. Reson.
Chem. IN PRESS

Unsymmetrical Covariance Processing of COSY or TOCSY and HSQC NMR Data to Obtain the Equivalent of HSQC-COSY and HSQC-TOCSY Spectra
Kirill A. Blinov,  Nicolay I. Larin, Antony J. Williams, K.A. Mills, and Gary E. Martin (Pfizer)
Magn. Reson.
Chem. IN PRESS

The Use of Unsymmetrical Indirect Covariance NMR Methods to Obtain the Equivalent of HSQC-NOESY Data
Kirill A. Blinov, Antony J. Williams, P.A. Irish (Schering-Plough),
Bruce D. Hilton (Schering-Plough), and Gary E. Martin (Schering-Plough)

Magn. Reson.
Chem. EARLY VIEW

Long-Range Carbon-Carbon Connectivity via Unsymmetrical Indirect Covariance Processing of HSQC and HMBC NMR Data
Kirill A. Blinov,  Nicolay I. Larin, Antony J. Williams, Mark Zell (Pfizer), and Gary E. Martin (Pfizer)

Magn. Reson.
Chem., 44, (2) 107-109, February 2006.

(The one above is actually the most accessed article on MRC’s website!)

Analysis and Elimination of Artifacts in Indirect Covariance NMR Spectra Via Unsymmetrical Processing
Kirill A. Blinov,  Nicolay I. Larin, Mikhail P. Kvasha, Arvin Moser, Antony J. Williams, and Gary E. Martin (Pfizer)
Magn. Reson. Chem., 43, (12) 999-1007, September 2005.

and several more in the works.

That should keep you busy for awhile…