Evaluate the likelihood of your compounds interacting with the P-glycoprotein transporter with ACD/P-gp Specificity | Percepta Predictors
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ACD/P-gp Specificity

Evaluate the likelihood of your compounds interacting with the P-glycoprotein transporter

P-glycoprotein (P-gp) is a clinically relevant efflux transporter that extrudes compounds from a large variety of cells. Its function has been associated with the drugs' absorption, distribution, excretion, CNS effects, multidrug resistance (MDR). P-gp transports a variety of natural compounds and drugs of different therapeutic areas.

Rapid identification of drug candidates that are P-gp substrates and/or inhibitors is possible using P-gp specificity model. Filtering and exclusion of P-gp substrates/inhibitors from huge 'in-house' libraries of synthesized compounds or virtual libraries is possible, followed by exclusion of such compounds from further development. P-gp specificity model may serve as an initial screen that could replace screening test based on P-gp ATPase activity measurements and partially replace expensive experiments with P-gp expressing cell monolayers and P-gp knock-out animals.

About the Model

Training set size:

The data sources in both cases consisted of more than 800 original publications in peer-reviewed scientific journals.

ACD/Labs Product Suites

The Percepta prediction modules are available as bundles to offer cost savings for multiple modules, and provide related modules as a package.

Deployment Options

ACD/P-gp Specificity Model predictions are available as a browser-based thin client application in Percepta Portal; a thick client product (Percepta for the Desktop); and a batch calculator (Percepta Batch).

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