Coupling benchtop NMR spectroscopy with the databasing capabilities of NMR Workbook Suite to boost illicit drug detection. This app note explores how this accessible, affordable, and automatable workflow enables seamless identification of highly cut street drug mixtures and can even detect derivatives or similar components—a valuable capability for New Psychoactive Substances (NPS) detection in forensic analysis. With advanced search modes and automated features, even non-NMR experts can easily identify potentially harmful substances.