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JOEL GARBOW
Biomedical MR Laboratory
Washington University School of Medicine
Campus Box 8227, 4525 Scott Avenue
St. Louis, MO 63110
314 362 9949
garbow@wuchem.wustl.edu
Summary of Professional Experience
Research chemist focused on physical and molecular characterization, principally through the development and application of magnetic-resonance methods. Ph.D. in Chemistry, University of California, Berkeley. Post-doctoral Fellow and staff scientist, Monsanto Corporate Research; promoted to Science Fellow in 1995. Recently joined Biomedical MR Laboratory, School of Medicine, Washington University. Strong technical, strategic, and project leadership; proven management skills. Demonstrated oral and written communication skills; well respected for team leadership, networking and research collaborations. Published extensively; recognized internationally in NMR.
Key Accomplishments
- Established world-class reputation in solid-state NMR; applied NMR methods as a problem-solving tool to study the structure and dynamics of a wide variety of molecular systems in the solid state, including polymorphic solids, polymers, biopolymers, and formulations.
- Managed Monsanto's St. Louis NMR laboratories, with its staff of 10 and a $3.4 M budget, through a period of active growth, hiring, and acquisition of new NMR technology, thereby increasing the labs' problem-solving capabilities.
- Advanced the development of new formulations through characterization of numerous polymer-based agrochemical and pharmaceutical formulations, including b-cyclodextrin inclusion complexes. NMR studies provided unique information about molecular structure, dynamics, morphology and aging effects.
- Supported new drug development by implementing solid-state NMR methods for characterizing polymorphs, including quantitative analyses of mixed polymorphic solids and determinations of polymorph content in pharmaceutical formulations.
- First industrial lab to perform rotational-echo double-resonance (REDOR); supported important programs across all business units by developing REDOR of isotopically-enriched materials as a problem-solving tool. Studies included peptide conformation, nylon aging, metabolism, and the distribution of drug mimetics in delivery matrices.
- In response to an incident at a chemical plant, provided the key critical analysis of plant and laboratory solids, confirming the cause of the operational failure and leading to the development of a plan to reconstruct the plant and improve its operation.
- Supplied data establishing an upper limit on residual agrochemical monomer in Monsanto commercial formulations. These data were the key component in response to the EPA, saving Monsanto from a costly and time-intensive analytical study.
- Proved oxidation was responsible for the premature aging of a key agricultural formulation additive, a finding which lead directly to significant cost savings through a change of storage conditions for this additive.
- Provided an important, new exploratory tool to support conventional and transgenic plant breeding programs through the development of quantitative, fully automated, high-resolution NMR analysis of oil composition in intact seeds and seed sections.
- Supported & enhanced research programs across all business units through the development of software for automated collection of NMR data and improved analysis & modeling of NMR data. Programming experience included UNIX administration and code written in FORTRAN, C, and Varian Magical.
- Published nearly 50 papers in peer-reviewed journals and delivered more than 20 invited talks at universities and regional & national scientific meetings.
Professional Work History
Biomedical MR Laboratory, Washington University,
Senior Scientist in Chemistry
Monsanto Corporate Research, St. Louis, MO,
Science Fellow (1995-1999)
Monsanto Corporate Research, St. Louis, MO,
Staff Scientist (1985-1995)
Monsanto Corporate Research, St. Louis, MO,
Post-Doctoral Fellow with Dr. Jacob Schaefer (1983-1984)
Professional Enhancements
Experimental NMR Conference (ENC), Member, Executive Committee, 1993-1999; ENC Secretary: 1996-1999
Rocky Mountain Conference on Analytical Chemistry, Conference Chair, NMR Symposium, 1996
St. Louis NMR Discussion Group, Co-chair, 1994-present
Education
Ph.D., Chemistry; University of California, Berkeley; Advisor: Professor Alex Pines
B. S., Chemistry, with Highest Honors; University of Illinois, Urbana-Champaign
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