High Throughput & Parallel Chemistry Software | Katalyst D2D®

Katalyst D2D®

High Throughput Experimentation Made Easier Than Ever Before

Katalyst D2D® Overview

Software to Streamline High Throughput Experiments from Design to Decide

Katalyst D2D (Design to Decide) is a browser-based software application that offers automated planning, execution, and analysis of high throughput experiments in a single interface.

Automated connection of live analytical data with each experiment means decisive and efficient decision-making. Use Katalyst for high throughput experimentation (HTE) in both discovery and development.

Benefits

User-Friendly & Efficient HTE with Data Integrity

Eliminate Transcription between Systems

Katalyst automates manual tasks and eliminates transcription between the multiple systems you currently use to plan and execute high throughput array-based chemistry or parallel synthesis.

Decide Faster with Automated Assembly of Results

Katalyst automatically assembles all your analytical data, from entire studies, in one place. So, you can comprehensively get from Design to Decide in one application.

Ensure Data Integrity

Reduce the risk of propagating errors through data transcription between systems—Katalyst automatically connects the data generated throughout the experiment to each individual well in the plate/array.

Automate Your HTE Workflow in One Interface

Katalyst is purpose-built to automate and analyze your entire high throughput and parallel chemistry workflow in one interface
Integrate with your networked hardware, laboratory execution systems, lab automation equipment, analytical instruments, and informatics systems

Centralized & Accessible High Throughput (HT) Data

Katalyst stores and organizes experimental and analytical data in one place, making it easier to find and available for further analysis
Browser-based software means you can view your experiments and data anywhere at any time—in adherence with security protocols established by your IT team

The Best Choice for Your Whole Team

Increased Efficiency

Reduce time spent assembling, managing, and sharing data
Execute experiments quicker with automatic procedure and robot worklists
Plan experiments faster with built-in templates and pre-dispensed plates (kits)

Seamless Sharing

Find and review data for your experiment efficiently with automatic data transfer from all the systems in your workflow, into the Katalyst interface
Access data from other experiments of interest, in the Katalyst interface. No need to be tied to the instrument lab or office computer to manage your data.

Structured Data

Katalyst delivers normalized, structured high throughput data that can be readily exported for use in data science applications

Contextualized Data

Connection of data throughout HTE workflows ensures context with data so that meaningful insights can be gained

Streamlined Deployment & Maintenance

Browser-based software means simpler roll-out, implementation of updates, and maintenance
Deploy on-premises or on the cloud (hosted in your environment)
Admin tools help you manage the application environment remotely, review problems, and provide resolution steps

Peace of Mind with Supported Integrations

Katalyst is designed to integrate with instrument hardware, software, and many applications typically used by HTE teams. Our professional services and support teams help ensure these integrations continue to operate as intended.

Intuitively design high throughput and parallel chemistry experiments. Drag-and-drop materials into the reaction scheme.

Plan HT experiments effortlessly with all your material sources accessible from one interface.

Generate machine readable files for robots or step-by-step instruction lists for manual execution.

Process and analyze all your analytical data, automatically linked to each well, in the same interface.

Visualize analytical results in series to make faster decisions. Reprocess data instantly when necessary.

How it Works

One Interface for Your High Throughput Experimentation

Request a Consultation or Demo

1 Design HT experiments in minutes
2 Plan HT experiments effortlessly
3 Execute HT experiments with ease
4 Analyze-automated, targeted analytical data processing
5 Decide with live analytical data and linked experiment information

Customer Reviews

“Colleagues not skilled with HTE were able to design a 96-well experiment in less than 5 minutes and get into the lab to run them the same day with Katalyst D2D.”

Kevin Arendt
BMS

“Katalyst D2D is a wonderful tool for high throughput chemistry. From initial fabrication of the experiment, to analysis and processing of the data—it keeps everything all in one place.”

David Battersby
GSK

Product Features

Import experimental designs created in third-party software (e.g. JMP)
Drag and drop pre-defined material classes (reagent, catalyst, ligand, solvent, etc.) into the Reaction Scheme to create your experimental design
Save and share experimental designs as templates
Source materials from connected inventory systems—corporate inventory, third-party sources, ad-hoc materials plates, pre-dispensed plates (kits)

Specify your unique lab automation equipment (reaction vessels, dispensing equipment) and unit operations
Define material locations, quantities, and concentrations for stock solutions and reaction arrays
Review and confirm your experiment plan using array-based visual layouts
Automatic creation of step-by-step instruction lists

Manual dispensing of materials

Generate a report with step-by-step instructions for weighing materials and preparing reagent stock solutions

Material dispensing via lab automation/robotics

Generate machine-readable files for import into instrument software
Send instructions directly to instruments
Plan downstream sample preparation for preparative chromatography, registration and inventory, and high throughput analytical data

Sampling for analysis

Prepare instruction lists for analytical instruments

Automatically perform targeted analytical data processing
- Process and analyze data from LC/MS, HPLC, UHPLC, and NMR instruments
- Native support for >150 instrument vendor data formats including Empower, MassLynx, ChemStation, LabSolutions, and Bruker
  Review the list of supported formats
Automatically associate results with each respective well in your high throughput experiment
Reprocess single data sets or entire plates of data on-demand through the web client

Visualize analytical results linked with the vessel or by well-plate location
Compare stacked chromatograms, spectra, and other analytical data
Export results to
- PDF, Microsoft Office Word/Excel/PowerPoint
- Third-party systems for further data analysis

Deployment/Integration Options

Deploy On-Cloud or On-Premises

Katalyst D2D has been successfully deployed both on-premises and client-hosted Cloud (e.g. AWS). We will help you with implementation and provide support for your deployment.

Tailored to Your Process & Environment

When it comes to complex workflows, one-size solutions will not fit everyone. We work with you to design the deployment and integration of Katalyst to serve your hardware, data, and software. Get the custom fit of an in-house solution with the quality and upkeep of a supported, commercial product.

Designed to Easily Integrate into Your Existing Informatics Infrastructure

Spend your time on reaction optimization, not administrative tasks.

Katalyst D2D has been designed to integrate with your laboratory execution systems, lab automation equipment, analytical instruments, and informatics systems.

So, instead of transcribing between systems or copy/pasting, you can concentrate on screening optimal catalysts, solvents, and reaction conditions to move projects along faster.

Systems That Integrate with Katalyst D2D

1Use your preferred Design of Experiments (DoE) tools and import into Katalyst D2D to get started.

2Integrate internal and external chemical inventories and sources to help plan your experiments. If you use pre-dispensed plates (kits), manage those in Katalyst too!

3When you’re ready to start your experiment, generate barcodes, sample IDs, and machine-readable instructions for dispensing equipment, automated reactors, and analytical instruments.

4Once your experiment is complete, the resulting data is automatically transferred to Katalyst. Analytical data (including LC, LC/MS, NMR) is automatically processed and made available for review.

5Generate a variety of reports that include all the relevant information. Integrate transfer of pertinent results into inventory and sample submission systems, if desired.

Compatible with All Your LC/MS & NMR Instruments

See All Supported Formats

Learn More about Katalyst D2D

Presentations

Enabling End-User HTE at GSK

K. Mercer, GSK

Hear how Katalyst D2D software has enabled GSK to streamline HTE design and execution and more efficiently capture high-quality data from these experiments.

Presentations

Addressing the Need for More Efficient Analytical Data Processing and Management in High Throughput Experimentation (HTE)

N. Dare, ACD/Labs

Learn how ACD/Labs software is used in R&D labs like yours to effectively digitize and manage analytical data, and increase efficiency.

Articles

The right tech can fill gap between lab scientist and data

Richard Lee discusses how automation, integration, and other tools can help with effective access and analysis of lab information.

Podcasts

Reaching New Heights with High Throughput Experimentation

Join us on a 4-decade journey through HTE. From the 80s and early 90s, to what's happening in pharmaceutical labs today, and what scientists hope for in the future.

Blog

5 Things to Consider When Creating or Expanding HTE Labs

The pharmaceutical industry has renewed its interest in HTE these last few years. Leaders see it as a way to get medicines to patients faster, but they’re also attracted by the sheer quantity of data generated in parallel experiments. How and where should HTE be set up for maximum success? Read this blog for questions that should be considered.

Webinars

Smash the Bottleneck of Analytical Data Processing in High Throughput Experimentation

See how Katalyst D2D can help streamline the processing and review of analytical data, directly associate analytical results with array…

Webinars

Practical Considerations for Improving High Throughput Synthesis

K. Arendt, BMS

Kevin Arendt of BMS showcases how they are using Katalyst D2D. An introduction to Katalyst D2D for those involved in…

Articles

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