Generic reversed-phase ultra-high-pressure liquid chromatography methodology developed by using computer-assisted modeling for streamlined performance evaluation of a wide range of stationary phase columns
This article highlights the use of Method Selection Suite as a generic method of selecting column and mobile phase eluent/buffer across different column chemistries and mobile phase pH ranges; delivering excellent results for the separation of a standard multicomponent mixture.
Automating processes using macros in ACD/Spectrus software
This presentation illustrates how NOVA chemical uses ACD/Labs Spectrus macros to strengthen and accelerate their impurities workflow in the synthesis and recycling of polyethylene products.
Working on the Unwanted. NMR support for impurity and contamination investigations at AZ Macclesfield
This presentation uses the examples of a contaminated freeze dryer, impure starting materials, and a hydrolyzing dendrimer to show how NMR can analyze impurities at all stages of the pharmaceutical workflow.
N-Nitrosamines: is the worst over?
This presentation provides an overview of the current state of research into N-nitrosamine impurities; what have we learned from systematic risk assessment, and what comes next.
Introduction to Using (Q)SAR for the Assessment of Potential Mutagenicity of Drug Impurities Under ICH M7
This presentation explains the fundamentals of computational toxicology as a critical aspect of modern impurities control.
Panel Discussion: Frontiers of Impurities Control
This panel conversation brings together a range of experts to discuss the problems and progress in impurities management.