In this study the crystallographic structure of the interaction between SARSCoV-2 (RBD) and ACE2 was used to determine compounds that could reduce the interaction between SARS-CoV-2 and ACE2; with these results compounds will be proposed to develop a new drug against COVID-19. PhysChem Suite was used to predict chemical properties of the compounds including toxicity, carcinogenicity, and mutagenicity.