This study proposes to carry out a molecular docking to select compounds capable of interacting in the catalytic site of TMPRSS2, to decrease the interaction between TMPRSS2 and S-protein, and generating a reduction in the entry of the virus into cells, to propose compounds to develop a new drug against SARS-CoV-2. PhysChem Suite was used to calculate chemical properties of the compounds, including toxicity, carcinogenicity, and mutagenicity.