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ACD/Labs Blog

The high throughput purification (HTP) group at Merck supports discovery chemistry to provide fast results for next step decisions. In this presentation, Jun discusses the use of vendor agnostic data management, chromatographic retention time prediction, and automation to drive greater efficiency in HTP. Hear about: Assembly of LC/UV/MS data from different instrument vendors Automated data...

Matt Osborne from AstraZeneca provides an overview of sustainability goals for green laboratories and how software can be employed to meet them—focused on chromatographic method development. Matt highlights how they use physicochemical prediction and chromatographic simulation software to achieve optimized, robust, and rugged methods with greater efficiency and sustainability.

Chromatography aims to separate an analyte mixture into sharp, symmetrical, and well-resolved peaks for quantitative and qualitative analysis. To do this, it is crucial to understand ionization and the ionic form(s) of analytes at a given pH. The use of predictive software tools allows quick selection of optimal conditions and helps build robustness into methods from the start.

Biopharmaceuticals are structurally complex and pose numerous challenges in drug development. Globally, R&D companies are working to combat the complicated drug analysis necessary for large molecules, while trying to reduce laborious method development. Scientists at Merck have incorporated retention modeling into their strategy to simplify and accelerate their method development. Their method development strategy involves...

How ACD/Labs Enables More Robust, Efficient Separations With the increasingly challenging demands confronted by separation scientists on their expertise, resources, and time, traditional chromatography approaches are often lacking. Chromatographers require advanced informatics solutions that offer comprehensive coverage of all method development functions. Learn how ACD/Labs’ strategies enable compliance with Quality by Design (QbD) regulatory expectations,...

Are you optimizing your method development strategies? Do you want to get better results faster? In this webinar, Gioacchino Luca Losacco (Postdoctoral Fellow Associate Scientist, Merck) presents how he and his colleagues integrated computer-assisted modeling into automated screening platforms to accelerate their method development and create robust workflows for small and large molecules.

The development of robust analytical assays for separation and analysis of complex multicomponent mixtures can often be challenging, reflecting the increased complexity of new medicine and vaccine processes. In silico liquid chromatography (LC) method development strategies for small molecules have reached a mature stage across the pharmaceutical industry. However, a straightforward approach for large molecules...

Présenté au Symposium ACD/Labs Paris 2022 Découvrir comment les logiciels d’ACD/Labs sont utilisés dans des laboratoires de R&D comme le vôtre pour numériser et gérer efficacement les données analytiques, et accroître l’efficacité. Découvrez des solutions qui apportent des avantages réels aux scientifiques de diverses industries : Pharmaceutique, Chimique, AgroSciences, et diverses activités: R&D, laboratoire d’analyse,...