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ACD/Labs Blog

Chromatography aims to separate an analyte mixture into sharp, symmetrical, and well-resolved peaks for quantitative and qualitative analysis. To do this, it is crucial to understand ionization and the ionic form(s) of analytes at a given pH. The use of predictive software tools allows quick selection of optimal conditions and helps build robustness into methods from the start.

The highly coveted Gaussian peak, a sharp symmetrical shape on a flat baseline, is the ideal peak shape in chromatography. Why is it so highly desired? Naturally, we tend to be drawn to the beauty of symmetry, but more importantly, good peak shape is important for better resolution (Rs) and increased accuracy in quantitation.

When Widener University switched to online teaching, Chemistry Professor Scott van Bramer turned to online tools as a way to continue educating his students. ACD/Method Selection Suite provided the answer to help his students run virtual experiments, and exposed them to the type of software they will see in their eventual workplaces.

There just doesn't seem to be enough hours in the day to get everything done. There are ways to gain time and be able to do more but they can be difficult to identify because until we’re exposed to them we carry on as we always have. If you are still doing any of the things discussed here, then there are ways you can gain hours in your day and even do your job better than you are right now!

We talk to a team at Dow AgroSciences about their decision to make changes in their laboratory to enable more efficient screening of method parameters. Using ACD/Labs’ method development software in their process enabled the team to implement a systematic approach to method development.

Gabriela Cimpan reflects on her career in chromatography with a specific look at the influence of Professor Simion Gorcan of Babes-Bolyai University. As she summarizes "Chromatography, like many other things, can be loved or hated. If you happen to love it maybe, like me, you too can attribute it to an inspiring personality in your life. I was taught a long time ago: 'Put a little passion in everything you do and you will succeed'."

In an effort to help separations scientists succeed in 2017, we decided to launch a webinar series aimed at informing the scientific community about how software can assist and improve method development strategies. Hosted by members of the ACD/Labs’ technical and scientific services team—Anne Marie Smith, Brent G. Pautler, and Karim Kassam—the webinar series consists of three 30-minute sessions on a variety of topics relating to method development.

TLC (Thin Layer Chromatography) offers a simple approach to identifying a solvent(s) for separating out a mixture, monitoring a reaction to completion, etc. Furthermore, the TLC plates can be stained to identify the presence or absence of various functional groups such as amines, ketones, etc. This qualitative experiment does offer various drawbacks. The process of...