Skip To Content

Resources

ACDLabs
Several organic molecules of low molecular weight (<150 Da) are demonstrated to have substantial membrane-lytic potential despite having a low predicted lipophilicity (logD < 1 at neutral pH). In aqueous liposome dispersions, 38 aromatic compounds were tested for their ability to either promote lipid hydrolysis or directly participate in chemical reactions with lipid molecules. Behaviors observed...

ACDLabs
Knowledge about the release behavior and drug retention properties of colloidal carriers is of essential importance for quality control as well as to predict in vivo performance. When conducting release studies from such systems, the release media should preferentially contain lipophilic acceptor components in order to mimic physiological conditions. In this study, transfer from a...

ACDLabs
C&EN spoke with three Pfizer scientists about their efforts to standardize access to analytical data, and the recent webinar they gave on the topic with ACD/Labs.

Sherry Myles
The role and importance of the identification of natural products are discussed in the perspective of the study of secondary metabolites. The rapid identification of already reported compounds, or structural dereplication, is recognized as a key element in natural product chemistry. The biological taxonomy of metabolite producing organisms, the knowledge of metabolite molecular structures, and...

ACDLabs
Le choix d’une méthode de séparation constitue une étape essentielle dans la mise au point de toute analyse par Chromatographie . Le fait, pour le chromatographiste, de disposer aujourd’hui d’un vaste éventail de méthodes et, à l’intérieur de celles-ci, d’une large gamme de phases stationnaires, ne simplifie pas ce choix, alors même qu’il présente, par...

ACDLabs
The wealth of analytical information that is generated every day in R&D organizations can provide rich insights, even months after the initial acquisition of data. With this increase in data, however, comes a significant challenge to combine, organize, access, visualize, and mine these informational repositories. In addition to the challenges of the growing volume and...