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ACD/Labs Blog

Sherry Myles
At GSK, Azzedine is responsible for in silico modeling for QbD method development and optimization. In this presentation, Azzedine presents a method development case study detailing decision steps that resulted in a robust and efficient method reached with the assistance of simulation, iterative optimization, and automated method screening using AutoChrom.

Sherry Myles
The high throughput purification (HTP) group at Merck supports discovery chemistry to provide fast results for next step decisions. In this presentation, Jun discusses the use of vendor agnostic data management, chromatographic retention time prediction, and automation to drive greater efficiency in HTP. Hear about: Assembly of LC/UV/MS data from different instrument vendors Automated data...

Baljit Bains
Chromatography aims to separate an analyte mixture into sharp, symmetrical, and well-resolved peaks for quantitative and qualitative analysis. To do this, it is crucial to understand ionization and the ionic form(s) of analytes at a given pH. The use of predictive software tools allows quick selection of optimal conditions and helps build robustness into methods from the start.

nvision
How ACD/Labs Enables More Robust, Efficient Separations With the increasingly challenging demands confronted by separation scientists on their expertise, resources, and time, traditional chromatography approaches are often lacking. Chromatographers require advanced informatics solutions that offer comprehensive coverage of all method development functions. Learn how ACD/Labs’ strategies enable compliance with Quality by Design (QbD) regulatory expectations,...

Sherry Myles
Chromatography is a powerful a flexible technique at all stages of chemistry research. Whether you are a graduate student attempting purify a compound or a pharmaceutical company attempting to test product quality, an effective chromatographic method is critical. But how do you develop these methods? Optimizing chromatography techniques is notoriously time consuming and frustrating work....

Joel Michalski
What do a racecar and an LC/MS system have in common? They’re both sophisticated machines whose performance must be measured by applicable standards. Scientists have long recognized the importance of standards, but with improvements in technology, the way we set them has changed. How can we use standardization to better communicate cutting-edge science? How can...

Joel Michalski
Imad Haidar Ahmad and colleagues at Merck present multifactorial peak crossover (MPC)—a new technique to quickly isolate peaks of interest. Using computer-assisted chromatographic modelling, the separation landscape is mapped and conditions that change peak-elution orders are found. Peaks of interest can be quickly shifted to convenient areas of the chromatogram, dramatically reducing the time spent...