Chromatography Archives - Page 5 of 7

Multi-column ultra-high performance liquid chromatography screening with chaotropic agents and computer-assisted separation modeling enables process development of new drug substances

Joel Michalski Feb 22, 2019

This article describes a simple approach for the development and implementation of an efficient ultra-high performance liquid chromatography (UHPLC) assay that is extensively applied to the separation and analysis of multicomponent reaction mixtures of closely related pharmaceutical intermediates and impurities. ACD/LC Simulator was used in conjunction with multi-column and multi-solvent UHPLC screening to optimize methods.

Generic anion-exchange chromatography method for analytical and preparative separation of nucleotides in the development and manufacture of drug substances

Joel Michalski Feb 22, 2019

This article discusses a generic ion-exchange method for analytical and preparative separation of nucleotides. This method was optimized using ACD/LC Simulator.

Achieve CHROMpliance: A 3-Step Strategy for Rational Method Development

Joel Michalski Dec 11, 2018

This webinar highlights how ACD/Labs’ software solutions for method optimization enable a 3-step strategy for rational method development that achieves CHROMpliance.

Chromatographic retention behaviour, modelling and optimization of a UHPLC-UV separation of the regioisomers of the Novel Psychoactive Substance (NPS) methoxphenidine (MXP)

Joel Michalski May 10, 2018

Software from ACD/Labs was used in the prediction of physical and chemical properties, and retention modelling and optimization.

A Practical Approach to Modelling of Reversed-Phase Liquid Chromatographic Separations: Advantages, Principles, and Possible Pitfalls

Joel Michalski Mar 1, 2018

This article presents the basic principles of modelling reverse phase LC separations for small and large molecules; and highlights the use of LC Simulator to perform the modelling.

Retention modelling in hydrophilic interaction chromatography (HILIC)

nvision Jan 30, 2018

Separation of hydrophilic and polar compounds (such as peptides) by HILIC can provide 10-1000 times increase in sensitivity compared to regular phase chromatography (RPC).

UHPLC Retention Time Prediction Using ACD/ChromGenius Increases Efficiency in Investigative Monitoring of Emerging Contaminants

Joel Michalski Dec 21, 2017

The retention time prediction capabilities of ACD/ChromGenius are outlined, and a suggestion of how these can be incorporated into a typical investigative water monitoring workflow is also included.

ACD/Labs the past, present, and future | Well wishes for 2018

Daria Thorp Dec 18, 2017

As 2017 comes to an end, Daria Thorp, President and CEO of ACD/Labs, looks back the company's 23 year history, and recounts some of its notable solutions, including ACD/Spectrus, ACD/Name and ACD/Percepta. She also discusses Luminata, ACD/labs' award winning impurity control informatics solution, which was introduced earlier this year.

Dow Designs Efficiencies into Method Development with Specialized Software

nvision Sep 19, 2017

Read about how AutoChrom supported high quality, consistent separations, and helped finalize a method in 2 days that the Dow AgroSciences team had spent months trying to optimize.

Adaptation of Retention Models to Allow Optimization of Peptide and Protein Separations

nvision Aug 17, 2017

Learn about adaptation of ACD/Method Selection Suite to model protein and peptide separations via RPC & IEC gradient chromatography, with the same simulation accuracy as for small molecules.

ACD/Labs Blog