Chromatography Archives - Page 6 of 7

Smarter Method Development – Webinar III: A 5 Step Strategy to Improve Complex Method Development with Software & Automation

Joel Michalski Mar 8, 2017

The number of variables that you can investigate to achieve the optimal method for complex samples can be overwhelming. This final webinar in our series (Smarter Method Development) highlights how software can provide a systematic and exhaustive approach towards method development with as much or as little expert intervention as desired. We will introduce you...

How “Smart” is Your Method Development?

Sanji Bhal Jan 27, 2017

In an effort to help separations scientists succeed in 2017, we decided to launch a webinar series aimed at informing the scientific community about how software can assist and improve method development strategies. Hosted by members of the ACD/Labs’ technical and scientific services team—Anne Marie Smith, Brent G. Pautler, and Karim Kassam—the webinar series consists of three 30-minute sessions on a variety of topics relating to method development.

Smarter Method Development – Webinar I: 3 Simple Ways Software Can Speed Your Method Development

Joel Michalski Jan 18, 2017

What is your method development strategy? This webinar is for you if you: Rely on knowledge and chemical intuition to choose a starting point Run iterative experiments to optimize methods Let us introduce you to some simple software tools that can help you speed up method development and optimization with minimal disruption to the way...

Chromatography Method Optimization (2 Parameters)

Joel Michalski Jan 4, 2017

Model and Optimize a two parameters (Gradient concentration & temperature, etc.) for LC separation in less time with fewer injections. 5.0min

Chromatography Method Optimization (1 Parameter)

Joel Michalski Jan 4, 2017

Model and Optimize a single parameter (pH, Gradient concentration, temperature, etc.) for LC Seperation in less time with fewer injections. 4.0min

Prediction Models of Retention Indices for Increased Confidence in Structural Elucidation during Complex Matrix Analysis: Application to Gas Chromatography Coupled with High-Resolution Mass Spectrometry

Joel Michalski Aug 2, 2016

This article discusses how using the mean of the LRI values predicted by RapidMiner and ACD/ChromGenius, in combination with accurate mass data, could enhance the confidence level for compound identification from the analysis of complex matrixes; the goal being to reduce the list of putative candidates to a reasonable number that can be obtained and...

Translations Between Differing Liquid Chromatography Formats: Advantages, Principles, and Possible Pitfalls

Joel Michalski Aug 1, 2014

The numerous advantages of translating gradient chromatographic methods between the differing formats of liquid chromatography (LC) have been explored and discussed. The authors investigate a number of potential pitfalls that may result in poor translations, and examine the consequences.

Better, Faster Method Development at Janssen

Joel Michalski Apr 7, 2014

Learn about how implementation of AutoChrom at Janssen Pharmaceuticals enabled an 80% reduction in method development time and 25-fold increase in method quality.

How Software Can Aid Decision-Making in Chromatographic Method Development

Joel Michalski Mar 26, 2013

Chromatographic method development continues to be one of the most challenging tasks for separations scientists today. In this article we discuss a comprehensive strategy for investigating design space and optimizing methods using ACD/AutoChrom software. A strategy that combines hardware, software, and personal and organizational knowledge is highlighted. Return on investment is also presented by scientists...

Qualitative Elucidation via TLC Staining

Arvin Moser Jan 20, 2010

TLC (Thin Layer Chromatography) offers a simple approach to identifying a solvent(s) for separating out a mixture, monitoring a reaction to completion, etc. Furthermore, the TLC plates can be stained to identify the presence or absence of various functional groups such as amines, ketones, etc. This qualitative experiment does offer various drawbacks. The process of...

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