Chromatography Archives - Page 7 of 9

Generic Ion Chromatography Conductivity Detection Method for Analysis of Palladium Scavengers in New Drug Substances

ACDLabs Apr 19, 2019

In this article, the use of ACD/LC Simulator to generate 3D resolution maps with separation conditions that matched the outcome of subsequent experimental data is discussed. Method validation experiments showed excellent analytical performance in linearity, recovery, repeatability, and loq/LOD.

Multi-column ultra-high performance liquid chromatography screening with chaotropic agents and computer-assisted separation modeling enables process development of new drug substances

ACDLabs Feb 22, 2019

This article describes a simple approach for the development and implementation of an efficient ultra-high performance liquid chromatography (UHPLC) assay that is extensively applied to the separation and analysis of multicomponent reaction mixtures of closely related pharmaceutical intermediates and impurities. ACD/LC Simulator was used in conjunction with multi-column and multi-solvent UHPLC screening to optimize methods.

Generic anion-exchange chromatography method for analytical and preparative separation of nucleotides in the development and manufacture of drug substances

ACDLabs Feb 22, 2019

This article discusses a generic ion-exchange method for analytical and preparative separation of nucleotides. This method was optimized using ACD/LC Simulator.

Achieve CHROMpliance: A 3-Step Strategy for Rational Method Development

ACDLabs Dec 11, 2018

This webinar highlights how ACD/Labs’ software solutions for method optimization enable a 3-step strategy for rational method development that achieves CHROMpliance.

Chromatographic retention behaviour, modelling and optimization of a UHPLC-UV separation of the regioisomers of the Novel Psychoactive Substance (NPS) methoxphenidine (MXP)

ACDLabs May 10, 2018

Software from ACD/Labs was used in the prediction of physical and chemical properties, and retention modelling and optimization.

A Practical Approach to Modelling of Reversed-Phase Liquid Chromatographic Separations: Advantages, Principles, and Possible Pitfalls

ACDLabs Mar 1, 2018

This article presents the basic principles of modelling reverse phase LC separations for small and large molecules; and highlights the use of LC Simulator to perform the modelling.

Advice for Implementing Method Development Software

Sanji Bhal Feb 15, 2018

We talk to a team at Dow AgroSciences about their decision to make changes in their laboratory to enable more efficient screening of method parameters. Using ACD/Labs’ method development software in their process enabled the team to implement a systematic approach to method development.

Retention modelling in hydrophilic interaction chromatography (HILIC)

ACDLabs Jan 30, 2018

Separation of hydrophilic and polar compounds (such as peptides) by HILIC can provide 10-1000 times increase in sensitivity compared to regular phase chromatography (RPC).

UHPLC Retention Time Prediction Using ACD/ChromGenius Increases Efficiency in Investigative Monitoring of Emerging Contaminants

ACDLabs Dec 21, 2017

The retention time prediction capabilities of ACD/ChromGenius are outlined, and a suggestion of how these can be incorporated into a typical investigative water monitoring workflow is also included.

Dow Designs Efficiencies into Method Development with Specialized Software

ACDLabs Sep 19, 2017

ACD/Labs Blog