ACD/Labs Blog

Securamine H Bryozoans belonging to the Flustridae family have been shown to be a rich source of structurally unique secondary metabolites. Hansen et al [1] examined the organic extract of Securiflustra securifrons. This resulted in the isolation of three new halogenated, hexacyclic indole-imidazole alkaloids, including securamine H(1), together with the previously known securamines C (2)...

Isatisindigoticanine I Ban Lan Gen, Isatis tinctoria L. (synonym Isatis indigotica Fort.), of the Brassicacene family, is a biennial herbaceous plant. It is widely cultivated and distributed in China, where its roots are used in Traditional Chinese Medicine (TCM) for the treatment of many diseases. Ban Lan Gen was studied, and a series of alkaloids...

Damirine B The indolocarbazole family of bisindole alkaloids is a well-known class of natural products. It’s best-known member is staurosporine, a protein kinase C inhibitor that belongs to the indolo[2,3‐a] carbazole structural class. Several other indolo[2,3‐a] carbazoles have so far been isolated and identified. However, only a limited number of other isomeric forms of indolocarbazole...

Peyssonnoside A Diterpenoids and their analogues and derivatives are well known and highly varied compounds.  Cyclopropane groups are also frequently encountered in natural products, but it is rare that highly substituted and/or embedded cyclopropanes are reported. The structural novelty of such compounds together with their bioactivity are valuable for medicinal, synthetic and biological chemists. Peyssonnoside...

Symmetric Helical Synthesis Product This month’s problem is again a bit different from the others. It comes from the Department of Chemistry, University of Bath, UK. John Lowe had been trying to challenge Structure Elucidator and asked his colleagues at the Department for interesting problems. David Carbery gave him two synthetic samples, A and B,...

Melohemsine J The plants of the genus Melodinus (Apocynaceae) include 53 species and several of them have been used in traditional Chinese medicine. They can be found in regions of southern China and, together with the Loganiaceae and Rubiaceae families they are known to contain many monoterpenoid indole alkaloids. For these reasons they have been...

Hypocrolide A A particular type of sesquiterpenoids are botryanes. The have the same basic skeleton of a bivyvliv nonisoprenoid system. They have only been found in a few fungal species, including the pathogen Botrytis cinereal, a necrotrophic plant. Since they are sesquiterpene metabolites they expected, and they do show, various biological activity. Yuan at al...

Leonuketal Leonurus Japonicus is a plant that is used in common traditional Chinese medicine. In fact, the aerial parts of it are in the Chinese Pharmacopoeia. Many diterpene metabolites have been discovered on plants of the same genus, with the common characteristics of the furanolabdane class. This class has been found to have interesting bioactivities...

Lucidumone Meroterpenoids are natural products containing a terpenoid and a non-terpenoid part. There have been many classes of such compounds isolated and characterized so far, from various natural sources, several of which have been found to have a wide range of biological activities. Meroterpenoids from various fungi usually show considerable biological activity and for this...