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ACD/Labs Blog

The group of M. Jaspars has been working with samples of Dermacoccus abyssi MT 1.1T, a piezotolerant Actinomycete. It was collected in 1998 and isolated in 2006 from a Mariana Trench sediment. A series of new phenazines were isolated and their structures elucidated. One of these compounds was dermacozine O.

Several types of polyketide-derived pigments can be found in crinoids. The group of Lum explored samples collected from different locations of the Great Barrier Reef. The analysis of C. rotalaria extracts by UHPLC-MS in conjunction with database searching led to the isolation and structure elucidation of a series of new taurine-conjugated anthraquinones, including comatulin A.

Lobocrassin A Cembrane-type metabolites are among the largest group of diterpenoids isolated from octocorals. A rich source of such compounds has been found to be Lobophytum crassum, a soft coral from the family of Alcyoniidae. This coral has been studied by Kao et al [1], and five new cembrane derivatives have been isolated. Amongst them...

The condensation of secologanin and tryptophan gives rise to the Monoterpene Indole Alacloids (MIAs). The unique feature in their structure is that they have 2 nitrogen atoms. MIAs are know to have good properties as drugs and hence have been studied extensively by scientists.  A potential source of MIAs is Gelsenium elegans (Gardn. & Champ.) known as “Duanchangcao” or “Dechayao”, amongst others.  It has been used in China as an analgesic and various MIAs have been isolated from its leaves, fruits, and roots.

Asperspiropene A Asperspiropene A (1) was first reported by He et al [1] as the second derivative of a class of compounds containing a unique six-membered ring substructure. The molecular formula was determined from the HR-MS spectrum to be C17H26O8. 1 Asperspiropene A showed a potent inhibitory effect on the cancer-associated mutant isocitrate dehydrogenase and...

Iridiod Glycoside Clerodendrum (Lamiaceae) is a genus composed of 580 species. It is found in tropical and subtropical regions and mainly includes small trees, shrubs, and herbs. Many members of the genus havebeen used in traditional medicine around the world. C. myricoides is a shrub with bluish flowers that has been used extensively in traditional...

Lyaline. Structure revision The original sample of lyaline was isolated from the roots of a Madagascan rubiaceous plant, Pauridiantha paucinervis in 1974. It was then reported to have a unique harman-1,4-dihydropyridine scaffold (1). That structure was determined only from EIMS and incomplete 1H NMR data, as recording 13C NMR spectra was not routinely available at that...

Davidone F Sophora davidii (Franch.) belong to the family Fabaceae and are shrubs or small trees found in China. Over the years many natural products have been isolated from them, including alkaloids, steroids, lignans, phenolic acids and, mostly, flavonoids. These have been found to have varying biological activities. The chemical investigation of S. davidii which...

Trichilianone D Trichilia species, a genus of plants from the Meliaceae family, are found in tropical forests and are used in traditional medicine. This species is poorly investigated and so a phytochemical study was published just recently [1]. This included the isolation of metabolites and the testing for antileishmanial activity. The study was focused on...